Glycogen Synthase Kinase-3 A Novel Regulator of Cardiac Hypertrophy and Development
نویسندگان
چکیده
Glycogen synthase kinase-3 (GSK-3 ) is a ubiquitously expressed constitutively active serine/threonine kinase that phosphorylates cellular substrates and thereby regulates a wide variety of cellular functions, including development, metabolism, gene transcription, protein translation, cytoskeletal organization, cell cycle regulation, and apoptosis. The activity of GSK-3 is negatively regulated by protein kinase B/Akt and by the Wnt signaling pathway. Increasing lines of evidence show that GSK-3 is an essential negative regulator of cardiac hypertrophy and that the inhibition of GSK-3 by hypertrophic stimuli is an important mechanism contributing to the development of cardiac hypertrophy. GSK-3 also plays an important role in regulating cardiac development. In this review, the role of GSK-3 in cardiac hypertrophy and development and the potential underlying mechanisms are discussed. (Circ Res. 2002;90:1055-1063.)
منابع مشابه
Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.
Glycogen synthase kinase-3beta (GSK-3beta) is a ubiquitously expressed constitutively active serine/threonine kinase that phosphorylates cellular substrates and thereby regulates a wide variety of cellular functions, including development, metabolism, gene transcription, protein translation, cytoskeletal organization, cell cycle regulation, and apoptosis. The activity of GSK-3beta is negatively...
متن کاملGlycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy
Hypertrophy is a basic cellular response to a variety of stressors and growth factors, and has been best characterized in myocytes. Pathologic hypertrophy of cardiac myocytes leads to heart failure, a major cause of death and disability in the developed world. Several cytosolic signaling pathways have been identified that transduce prohypertrophic signals, but to date, little work has focused o...
متن کاملInhibition of Glycogen Synthase Kinase 3 During Heart Failure Is Protective
Glycogen synthase kinase (GSK)-3, a negative regulator of cardiac hypertrophy, is inactivated in failing hearts. To examine the histopathological and functional consequence of the persistent inhibition of GSK-3 in the heart in vivo, we generated transgenic mice with cardiac-specific overexpression of dominant negative GSK-3 (Tg-GSK-3 -DN) and tetracycline-regulatable wild-type GSK-3 . GSK-3 -DN...
متن کاملThe role of glycogen synthase kinase-3 and camp response element-binding protein in the induction and regulation of cardiac hypertrophy in neonatal rat ventricular myocytes
متن کامل
Inhibition of glycogen synthase kinase 3beta during heart failure is protective.
Glycogen synthase kinase (GSK)-3, a negative regulator of cardiac hypertrophy, is inactivated in failing hearts. To examine the histopathological and functional consequence of the persistent inhibition of GSK-3beta in the heart in vivo, we generated transgenic mice with cardiac-specific overexpression of dominant negative GSK-3beta (Tg-GSK-3beta-DN) and tetracycline-regulatable wild-type GSK-3b...
متن کامل